Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms

Autor: Celia Snyman, Sharda Sawant, Kanti D. Bhoola
Rok vydání: 2001
Předmět:
Pathology
medicine.medical_specialty
Proteases
Receptor
Bradykinin B2
Receptor expression
Peptic
Immunology
Tissue kallikrein
Adenocarcinoma
Biology
Receptor
Bradykinin B1
Helicobacter Infections
Malignant transformation
Immunoenzyme Techniques
Stomach Neoplasms
Image Processing
Computer-Assisted
medicine
Humans
Immunology and Allergy
Stomach Ulcer
cardiovascular diseases
Pharmacology
Enzyme Precursors
Microscopy
Confocal
Helicobacter pylori
urogenital system
Receptors
Bradykinin
Stomach
Carcinoma
Cancer
Cell Differentiation
Kinin
medicine.disease
Immunohistochemistry
digestive system diseases
Neoplasm Proteins
Gene Expression Regulation
Neoplastic
Cell Transformation
Neoplastic
medicine.anatomical_structure
Gene Expression Regulation
Gastritis
Kallikreins
Tissue Kallikreins
circulatory and respiratory physiology
Zdroj: International Immunopharmacology. 1:2063-2080
ISSN: 1567-5769
DOI: 10.1016/s1567-5769(01)00118-7
Popis: Recent studies have suggested the possible involvement of the kallikrein–kinin cascade in gastric inflammatory diseases and malignant transformation in peptic ulcers. Germ-line mutations of genes responsible for repairing DNA mismatch may cause the transformation of chronic peptic ulceration to malignancy. The aim of the study was to compare the expression of the serine protease, tissue kallikrein (TK) and kinin peptide receptors, B1 and B2, in human gastric carcinoma and ulcers. Furthermore, experiments were designed to ask the question whether holistic changes known to occur in carcinoma would be reflected in the expression of the neutrophil kallikrein–kinin cascade. Expression of tissue kallikrein and kinin receptors in both tumour and ulcer tissue and circulating neutrophils of cancer and ulcer patients was determined by immunolabelling techniques, using specific antibodies. The immunolabelled images were visualised by light, confocal and electron microscopy. This is a first study that provides strong evidence for enhanced expression of TK in peptic ulceration and gastric malignancy, suggestive of a crucial role for serine proteases in cancer.
Databáze: OpenAIRE
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