Imaging skeletal muscle volume, density, and FDG uptake before and after induction therapy for non-small cell lung cancer
| Autor: | Emily Schwitzer, Darragh Halpenny, Samuel Taylor, Mark Dunphy, J. Jackson, Stephanie Gandelman, Marcus D. Goncalves, Lee W. Jones, Kay See Tan, A. Lukose, R.J. Downey, Andrew J. Plodkowski |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Lung Neoplasms medicine.medical_treatment Article 03 medical and health sciences 0302 clinical medicine Lumbar Fluorodeoxyglucose F18 Induction therapy Carcinoma Non-Small-Cell Lung Positron Emission Tomography Computed Tomography Weight Loss Medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Muscle Skeletal Aged Neoplasm Staging Chemotherapy business.industry Skeletal muscle Induction chemotherapy General Medicine Middle Aged medicine.disease Survival Rate 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female Tomography Non small cell Radiopharmaceuticals business Nuclear medicine Tomography X-Ray Computed |
| Popis: | AIM: To assess whether changes in body composition could be assessed serially using conventional thoracic computed tomography (CT) and positron-emission tomography (PET)/CT imaging in patients receiving induction chemotherapy for non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: CT-based skeletal muscle volume and density were measured retrospectively from thoracic and lumbar segment CT images from 88 patients with newly diagnosed and untreated NSCLC before and after induction chemotherapy. Skeletal muscle 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) uptake was measured from PET/CT images from a subset of patients (n=42). Comparisons of each metric before and after induction chemotherapy were conducted using the non-parametric Wilcoxon signed-rank test for paired data. The association between clinical factors and percentage change in muscle volume was examined using univariate linear regression models, with adjustment for baseline muscle volume. RESULTS: Following induction chemotherapy, thoracic (−3.3%, p=0.0005) and lumbar (−2.6%, p=0.0101) skeletal muscle volume were reduced (adiposity remained unchanged). The proportion of skeletal muscle with a density |
| Databáze: | OpenAIRE |
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