Additional file 1: Figure S1. of Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

Autor: Hujber, Zoltán, Petővári, Gábor, Szoboszlai, Norbert, Titanilla Dankó, Nagy, Noémi, Kriston, Csilla, Krencz, Ildikó, Paku, Sándor, Olivér Ozohanics, Drahos, László, Jeney, András, Sebestyén, Anna
Rok vydání: 2017
DOI: 10.6084/m9.figshare.c.3794833_d1
Popis: Adding 2-HG, lactate did not influence the anti-proliferative effect of rapamycin treatment in HT-1080 cells. The in vitro anti-proliferative effect of rapamycin (50 ng/ml), Na-L-lactate (5 mM) and D-2-HG (0.5 mM) combination treatments were studied by Alamar Blue test after 48–72 h (the results of a representative experiment n = 6, *:p
Databáze: OpenAIRE