Enhanced cytotoxicity of gold porphyrin complexes after inclusion in cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles
| Autor: | Bertrand Liagre, Gautier Mark Arthur Ndong Ntoutoume, René Faure, Robert Granet, Jean Pierre Mbakidi, David Yann Leger, Vincent Sol |
|---|---|
| Přispěvatelé: | Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), PEIRENE (PEIRENE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Porphyrins
[SDV]Life Sciences [q-bio] Clinical Biochemistry Pharmaceutical Science Nanoparticle Metal Nanoparticles [SDV.CAN]Life Sciences [q-bio]/Cancer [SDV.BC]Life Sciences [q-bio]/Cellular Biology 01 natural sciences Biochemistry chemistry.chemical_compound Adsorption Coordination Complexes Cell Line Tumor Drug Discovery Humans Polyethyleneimine [CHIM]Chemical Sciences Cytotoxicity Molecular Biology ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification Cyclodextrins Cyclodextrin 010405 organic chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Combinatorial chemistry Porphyrin 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Colloidal gold Cancer cell Molecular Medicine Gold |
| Zdroj: | Bioorganic and Medicinal Chemistry Letters Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (9), pp.1065-1068. ⟨10.1016/j.bmcl.2019.03.003⟩ |
| ISSN: | 0960-894X |
| Popis: | A new gold nanoparticle-based construct has been designed to hydrophobic drugs delivery into cancer cells. Cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles (AuNP@PEI@CD) have been used to encapsulate hydrophobic tetrapyrrolic compounds consisting of gold complexes of 5,10,15,20-tetraphenyl porphyrin (AuTPPCl) and 5-(4-acetoxyphenyl)-10,15,20-triphenyl porphyrin (AuTPPOAcCl). These two nanoparticles have been tested for their cytotoxic activities against the two colorectal cancer cell lines HT-29 and HCT-116 and have shown significant increases in toxicity when compared to the corresponding non-vectorized tetrapyrrolic macrocycles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect