The Association of rs1047763 and rs1008898 of C1GALT1 with IgA Nephropathy Risk: A Global Meta-Analysis
| Autor: | Jin Zhang, Chen Wang, Yu Dong, Jianhua Liu, Ruili Nie, Xiaosong Qin, Guixue Cheng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Glycosylation medicine.drug_class Immunology Gene Expression Biology urologic and male genital diseases Monoclonal antibody Polymorphism Single Nucleotide Nephropathy 03 medical and health sciences chemistry.chemical_compound Gene Frequency medicine Humans Immunology and Allergy Allele Alleles Models Genetic Glomerulonephritis IGA Glomerulonephritis Galactosyltransferases medicine.disease Immunoglobulin A 030104 developmental biology chemistry Case-Control Studies Meta-analysis Mesangial Cells biology.protein Antibody C1GALT1 |
| Zdroj: | Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36:95-103 |
| ISSN: | 2167-9436 |
| DOI: | 10.1089/mab.2016.0050 |
| Popis: | IgA nephropathy (IgAN) is a globally common primary glomerulonephritis characterized by an elevated level of serum IgA and immune complex deposition in the mesangial area. In the serum of patients with IgAN, the hinge region of IgA1 immunoglobulin contains aberrantly glycosylated O-glycans deficient in galactose, which is normally added to the core 1 O-glycan structure by core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1), the key enzyme in the process of glycosylation. It is unknown if single-nucleotide polymorphisms rs1047763 and rs1008898 of C1GALT1 increase the risk of IgAN. We enrolled 5 subjects in this meta-analysis, including a total of 1693 IgAN patients and 1864 control subjects. We performed meta-analysis on associations between rs1047763, rs1008898, and IgAN using the allele model, dominant model, recessive model, and additive model. We found that there was no relationship between rs1047763 and rs1008898 in C1GALT1 and susceptibility to IgAN. |
| Databáze: | OpenAIRE |
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