Pharmacokinetic Behaviour of Enrofloxacin after Single Intramuscular Dosage in American Black Vultures (Coragyps atratus)
| Autor: | Laura Torres Bianchini, Samanta Waxman, Casilda Rodríguez, Guillermo Wiemeyer, José Julio de Lucas, Manuel Ignacio San Andres |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Farmacología veterinaria Veterinary medicine animal diseases Cmax Mycoplasma synoviae Absorption (skin) RM1-950 Biochemistry Microbiology Pharmacokinetics Animales salvajes y exóticos medicine Enrofloxacin Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics pharmacokinetic PK/PD models Active metabolite Monte Carlo simulation Chemistry PK/PD biochemical phenomena metabolism and nutrition Ciprofloxacin Infectious Diseases black vultures Therapeutics. Pharmacology enrofloxacin medicine.drug |
| Zdroj: | Antibiotics, Vol 10, Iss 957, p 957 (2021) E-Prints Complutense. Archivo Institucional de la UCM instname Antibiotics Volume 10 Issue 8 |
| ISSN: | 2079-6382 |
| Popis: | The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints. |
| Databáze: | OpenAIRE |
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