Prepulse modulation and recovery of trigemino-cervical reflex in normal subjects
| Autor: | Pınar Bekdik Şirinocak, Burcu Nuran Arkalı, Tuba Akıncı, Fatma Candan, Meral E. Kiziltan, Aysegul Gunduz, Tuba Cerrahoğlu Şirin |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Neurology chemical and pharmacologic phenomena Dermatology Stimulus (physiology) Fingers 03 medical and health sciences Infraorbital nerve 0302 clinical medicine Reflex Pedunculopontine Tegmental Nucleus medicine Humans 030212 general & internal medicine Corneal reflex Prepulse inhibition Prepulse Inhibition business.industry T-cell receptor hemic and immune systems General Medicine Middle Aged Electric Stimulation Psychiatry and Mental health Face Head Movements Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurological Sciences. 40:305-310 |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | In this study, we analyzed the inhibitory control on the trigemino-cervical reflex (TCR), and whether or not prepulse modulation (PPM) has an effect on TCR. Thus, we studied the PPM of TCR. We hypothesized that TCR would presumably be under the modulatory effect after the prepulse stimulus similar to blink reflex (BR). We also studied the recovery of TCR which was previously shown. We included 13 healthy individuals. All subjects underwent recordings of TCR, TCR-PPM, and recovery of TCR. For TCR-PPM, a subthreshold stimulus to second finger 50 or 100 ms before the test stimulus was applied. For recovery of TCR, two stimuli at the infraorbital nerve were applied at 300, 500, and 800 ms interstimulus intervals (ISIs). There was an inhibition of bilateral late responses of TCR at the ISIs of both 50 ms and 100 ms. There was no change of latencies. Full recovery of TCR did not develop even at the ISI 800 ms. We have provided an evidence for the TCR-PPM in healthy subjects for the first time in this study. The prepulse inhibition is attributed to the functions of the pedunculopontine tegmental nucleus. Our study provides a strong indication that there are connections between pedunculopontine tegmental nucleus and trigemino-cervical circuit, which produces TCR. |
| Databáze: | OpenAIRE |
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