Utilization of small changes in serum creatinine with clinical risk factors to assess the risk of AKI in critically lll adults
| Autor: | Cruz, Dn, Piccinni, P, Garzotto, F, Gramaticopolo, S, Ronco, C, Dal Santo, M, Brienza, N, Iannuzzi, M, Forfori, Francesco, Giunta, Francesco, Pelaia, P, Gabbanelli, V, Belluomo Anello, C, Alessandri, E, Rocco, M, Bove, T, Carlini, M, Montini, L, Antonelli, M, Michetti, V. |
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| Přispěvatelé: | Cruz, Dn, Ferrer Nadal, A, Piccinni, P, Goldstein, Sl, Chawla, L, Alessandri, E, Belluomo Anello, C, Bohannon, W, Bove, T, Brienza, N, Carlini, M, Forfori, F, Garzotto, F, Gramaticopolo, S, Iannuzzi, Michele, Montini, L, Pelaia, P, Ronco, C, for the NEFROINT, Investigators |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Time Factors ILL PATIENTS Epidemiology MULTICENTER urologic and male genital diseases Critical Care and Intensive Care Medicine SOFA SCORE law.invention chemistry.chemical_compound Risk Factors law Clinical endpoint Prospective Studies Prospective cohort study ANGINA Age Factors Acute kidney injury Acute Kidney Injury Middle Aged RIFLE Prognosis Intensive care unit Up-Regulation Intensive Care Units Italy Nephrology Area Under Curve Creatinine Female Risk assessment Cohort study Adult medicine.medical_specialty Critical Illness Context (language use) Risk Assessment Predictive Value of Tests Settore MED/41 - ANESTESIOLOGIA medicine Humans Intensive care medicine Aged Transplantation business.industry acute kidney injury renal failure mortality Original Articles medicine.disease ROC Curve chemistry ICU Emergency medicine ACUTE KIDNEY INJURY ACUTE-RENAL-FAILURE CARDIAC-SURGERY EPIDEMIOLOGY business Biomarkers |
| Popis: | BACKGROUND AND OBJECTIVES: Disease biomarkers require appropriate clinical context to be used effectively. Combining clinical risk factors, in addition to small changes in serum creatinine, has been proposed to improve the assessment of AKI. This notion was developed in order to identify the risk of AKI early in a patient's clinical course. We set out to assess the performance of this combination approach. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A secondary analysis of data from a prospective multicenter intensive care unit cohort study (September 2009 to April 2010) was performed. Patients at high risk using this combination approach were defined as an early increase in serum creatinine of 0.1-0.4 mg/dl, depending on number of clinical factors predisposing to AKI. AKI was defined and staged using the Acute Kidney Injury Network criteria. The primary outcome was evolution to severe AKI (Acute Kidney Injury Network stages 2 and 3) within 7 days in the intensive care unit. RESULTS: Of 506 patients, 214 (42.2%) patients had early creatinine elevation and were deemed at high risk for AKI. This group was more likely to subsequently develop the primary endpoint (16.4% versus 1.0% [not at high risk], P |
| Databáze: | OpenAIRE |
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