Transmission dynamics of SARS‐CoV‐2 within families with children in Greece: a study of 23 clusters
| Autor: | Athanasia Lourida, Symeon Metallidis, Kalliopi Papadima, Athanasios Tsakris, Andreas Mentis, Rengina Vorou, Elisavet Froukala, Beatriz Martinez-Gonzalez, Maria Exindari, Nikolaos Spanakis, Anna Papa, Emmanuel Roilides, Vasilios Raftopoulos, Helena C. Maltezou, Georgia Gioula, Athanasios Kossyvakis, Athanasios Mitsianis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty family Adolescent Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Attack rate Asymptomatic Severity of Illness Index SARS‐CoV‐2 03 medical and health sciences Young Adult 0302 clinical medicine children COVID‐19 Internal medicine Virology Severity of illness medicine Humans 030212 general & internal medicine Young adult Respiratory system cluster Child Asymptomatic Infections Research Articles Aged Aged 80 and over Family Health Greece business.industry Transmission (medicine) SARS-CoV-2 COVID-19 Infant Middle Aged Viral Load Infectious Diseases Disease Hotspot Child Preschool 030211 gastroenterology & hepatology Female medicine.symptom business Viral load Research Article |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | Background There is limited information on SARS‐CoV‐2 infection clustering within families with children. We aimed to study the transmission dynamics of SARS‐CoV‐2 within families with children in Greece. Methods We studied 23 family clusters of COVID‐19. Infection was diagnosed by RT‐PCR in respiratory specimens. The level of viral load was categorized as high, moderate, or low based on the cycle threshold values. Results There were 109 household members (66 adults and 43 children). The median attack rate per cluster was 60% (range: 33.4%‐100%). An adult member with COVID‐19 was the first case in 21 (91.3%) clusters. Transmission of infection occurred from an adult to a child in 19 clusters and/or from an adult to another adult in 12 clusters. There was no evidence of child‐to‐adult or child‐to‐child transmission. In total 68 household members (62.4%) tested positive. Children were more likely to have an asymptomatic SARS‐CoV‐2 infection compared to adults (40% versus 10.5%, p‐value=0.021). In contrast, adults were more likely to develop a severe clinical course compared to children (8.8% versus 0%, p‐value=0.021). In addition, infected children were significantly more likely to have a low viral load while adults were more likely to have a moderate viral load (40.7% and 18.5% versus 13.8% and 51.7%, respectively; p‐value=0.016). Conclusions While children become infected by SARS‐CoV‐2, they do not appear to transmit infection to others. Furthermore, children more frequently have an asymptomatic or mild course compared to adults. Further studies are needed to elucidate the role of viral load on these findings. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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