Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals
| Autor: | Xiaoming Shi, Yue Bin Lv, Wen Fang Zhong, Xian Bo Wu, Qing Mei Huang, Zhi-Hao Li, Virginia B. Kraus, Chen Mao, Jin Dong Ni, Pei Liang Chen, Xiang Gao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Aging Cardiovascular mortality Immunology Cancer mortality Clinical nutrition lcsh:Geriatrics 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Medicine Medical history 030212 general & internal medicine Prospective cohort study biology business.industry Research Confounding Hazard ratio C-reactive protein All-cause mortality Confidence interval lcsh:RC952-954.6 High-sensitivity C-reactive protein Quartile biology.protein lcsh:RC581-607 business Demography |
| Zdroj: | Immunity & Ageing : I & A Immunity & Ageing, Vol 16, Iss 1, Pp 1-8 (2019) |
| ISSN: | 1742-4933 |
| DOI: | 10.1186/s12979-019-0168-5 |
| Popis: | Background The association of high-sensitivity C-reactive protein (hsCRP) with mortality is controversial. We aimed to investigate the associations of hsCRP concentrations with the risks of all-cause and cause-specific mortality and identify potential modifying factors affecting these associations among middle-aged and elderly individuals. Methods This community-based prospective cohort study included 14,220 participants aged 50+ years (mean age: 64.9 years) from the Health and Retirement Study. Cox proportional hazard models were employed to estimate the associations between the hsCRP concentrations and the risk of all-cause and cause-specific mortality with adjustment for sociodemographic and lifestyle factors, self-reported medical history, and other potential confounders. Results In total, 1730 all-cause deaths were recorded, including 725 cardiovascular- and 417 cancer-related deaths, after an 80,572 person-year follow-up (median: 6.4 years; range: 3.6–8.1 years). The comparisons of the groups with the highest (quartile 4) and lowest (quartile 1) hsCRP concentrations revealed that the adjusted hazard ratios and 95% confidence intervals were 1.50 (1.31–1.72) for all-cause mortality, 1.44 (1.13–1.82) for cardiovascular mortality, and 1.67 (1.23–2.26) for cancer mortality. The associations between high hsCRP concentrations and the risks of all-cause, cardiovascular, and cancer mortality were similar in the men and women (P for interaction > 0.05). Conclusions Among middle-aged and older individuals, elevated hsCRP concentration could increase the risk of all-cause, cardiovascular, and cancer mortality in men and women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink