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The aim of present work is to formulate and evaluate buccal tablets of protonix (pantoprazole sodium) which is subjected to first pass effect and having short half life. To increase the bio availability of a protonix by delivering through the buccal mucosa, as it is a potential site for direct delivery of drugs into systemic circulation. To control the drug release from the tablets by using matrix forming bioadhesive polymers, as the half life of drug is very low. To study the effect of drug : polymer ratio on drug release and other bioadhesive properties. Key words: Buccal, Protonix, Bioadhesive, Systemic circulation, Half life |
