A prospective trial of steroid withdrawal after renal transplantation treated with cyclosporine and mizoribine in children: Results obtained between 1990 and 2003
| Autor: | Motoshi Hattori, Takehiro Ohara, Osamu Motoyama, Seiichirou Shishido, A Hasegawa, Kazuhide Saito, Kazuo Tsuzuki, K. Ito, Mari Satoh, Kota Takahashi, Tsuneo Kinukawa, Masataka Honda, Toshio Yanagihara, Shinichi Ohshima, Osamu Ogawa |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Adolescent medicine.drug_class Urinary system Methylprednisolone Humans Medicine Prospective Studies Child Glucocorticoids Growth Disorders Transplantation Kidney Mizoribine business.industry Prognosis Ciclosporin Kidney Transplantation Body Height Surgery Clinical trial medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Cyclosporine Corticosteroid Drug Therapy Combination Female Ribonucleosides business Immunosuppressive Agents medicine.drug |
| Zdroj: | Pediatric Transplantation. 9:232-238 |
| ISSN: | 1399-3046 1397-3142 |
| DOI: | 10.1111/j.1399-3046.2005.00255.x |
| Popis: | A prospective trial of adrenocorticostertoid (steroid) withdrawal after pediatric renal transplantation was begun in 1990. Ninety-four pediatric renal transplant recipients were enrolled in our multicenter study. Immunosuppressive therapy with cyclosporine (CyA), methylprednisolone (MPL), and mizoribine (MZ) was started after transplantation. MPL was reduced to administration on alternate days in 69 patients (73.4%) and was withdrawn in 27 patients (28.7%). Rejection episodes occurred in nine patients (33.3%) after withdrawal of MPL. It occurred within 3 months after withdrawal of MPL in two patients and more than 6 months in the others. Among them, two patients lost the grafts. Thirteen-year patient survival rate and graft survival rate were 94.6 and 83.1%, respectively. Forty-four of the 94 patients reached their final height. Mean final height was 155.0 cm in males and 146.3 cm in females and their height standard deviation score was -2.6 s.d., the same as that at the time of transplantation. Management of growth retardation before transplantation and further reduction in the steroid dose after transplantation will increase the final height of children with chronic renal failure. |
| Databáze: | OpenAIRE |
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