Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway
| Autor: | Yinghua Li, Songyi Li, Lili Huang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research MAP Kinase Signaling System Proliferation Uterine Cervical Neoplasms Biology medicine.disease_cause Article Metastasis Mice 03 medical and health sciences Invasion Cell Movement Cell Line Tumor Anti-apoptotic Ras signalling cascade medicine Animals Humans Neoplasm Invasiveness Migration Cell Proliferation Oncogene Proteins Cervical cancer Mice Inbred BALB C RAS Superfamily Protein Gene knockdown Oncogene Oncogenes General Medicine medicine.disease Cell biology Gene Expression Regulation Neoplastic rap GTP-Binding Proteins 030104 developmental biology Oncology Rap2B Cancer research Heterografts Female Ras superfamily Carcinogenesis |
| Zdroj: | Oncology Research |
| ISSN: | 0965-0407 |
| DOI: | 10.3727/096504017x14912172235777 |
| Popis: | Rap2B, belonging to the Ras superfamily, has been implicated in cancer development and functions as a tumor promoter. However, the role of Rap2B in cervical cancer is unknown. In this study, we investigated the expression pattern and biological functions of Rap2B in cervical cancer. The results showed that Rap2B was overexpressed in cervical cancer tissues and cell lines. Knockdown of Rap2B inhibited the proliferation, migration, and invasion of cervical cancer cells. In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo. We also found that the ERK1/2 signaling pathway is involved in the inhibitory effect of Rap2B knockdown on cervical cancer development. In conclusion, we suggest that Rap2B is an oncogene and may be a promising therapeutic target for cervical cancer. |
| Databáze: | OpenAIRE |
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