A New Synthetic Conduit for the Treatment of Peripheral Nerve Injuries
| Autor: | Dietmar Rafolt, Reinhold Kleinert, Jörg Waldert, G. Tomasch, Selman Uranues, H. Koch, Ivo Justich, Georg Bretthauer, Doris Nagele-Moser, Andrea Berghold |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Original Scientific Report Swine Nerve guidance conduit Prosthesis Design Neurosurgical Procedures Random Allocation 03 medical and health sciences 0302 clinical medicine Electrical conduit Peripheral Nerve Injuries Peripheral nerve medicine Animals 030304 developmental biology Titanium 0303 health sciences business.industry Muscles DATA processing & computer science Nerve graft Treatment options Prostheses and Implants Evoked Potentials Motor Sciatic Nerve Nerve Regeneration Surgery Models Animal Gelatin Swine Miniature ddc:004 Atrophy Gait Analysis business 030217 neurology & neurosurgery |
| Zdroj: | World Journal of Surgery World journal of surgery, 44, 3373–3382 |
| ISSN: | 0364-2313 1432-2323 |
| DOI: | 10.5445/ir/1000120839 |
| Popis: | Background Peripheral nerve defects (PND) often cause lifelong physical disability, and the available treatment options are often not satisfactory. PND are usually bridged with an autologous nerve transplant or a nerve guidance conduit (NGC), when coaptation as preferred technique is not possible. The aim of this experimental study was to determine the effectiveness of a novel NGC for regeneration in the treatment of PND. Materials and methods A conduit made of gelatin with an innovative interior structure was tested for the repair of a 6-mm gap versus direct microsurgical suture repair without gap. Results We found that bridging the defect with this conduit was as effective as direct microsurgical coaptation without a defect. Conclusions This nerve conduit, effective in bridging neural defects, appears as an alternative to autologous nerve grafts, avoiding the problems related to nerve graft harvesting, host–donor differences in diameter, mismatches in number and pattern of fascicles, cross-sectional shape and area, and morbidity of the donor area. |
| Databáze: | OpenAIRE |
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