Effects of red ginseng on the elastic properties of human skin
| Autor: | Jin-Woo Lee, Kyung Sook Kim, Se Jik Han, Sangwoo Kwon, Moon Young Park, Donggerami Moon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
H&E stain Human skin macromolecular substances Biochemistry Genetics and Molecular Biology (miscellaneous) complex mixtures 03 medical and health sciences Ginseng Atomic force microscopy 0302 clinical medicine lcsh:Botany medicine Skin equivalent Red ginseng Cytoskeleton Fibroblast Skin elasticity Pharmacology & Physiology biology integumentary system Chemistry Cellular stiffness food and beverages lcsh:QK1-989 030104 developmental biology medicine.anatomical_structure Complementary and alternative medicine 030220 oncology & carcinogenesis Biophysics biology.protein Collagen Elastin Biotechnology |
| Zdroj: | Journal of Ginseng Research Journal of Ginseng Research, Vol 44, Iss 5, Pp 738-746 (2020) |
| ISSN: | 2093-4947 1226-8453 |
| Popis: | Background Red ginseng contains components, including microelements, vitamins, essential oils, and fatty acids, that can be used in skincare to delay the aging process. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis. Methods Human dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using atomic force microscopy. Cytoskeletal changes and mRNA expression of biomarkers of aging, including that of procollagens I and VII, elastin, and fibrillin-1, were investigated. Collagen in a human skin equivalent treated with red ginseng was visualized via hematoxylin and eosin staining, scanning electron microscopy, and atomic force microscopy. Results and conclusion The stiffness of fibroblasts was significantly reduced by treatment with red ginseng concentrations of ≥ 0.8 mg/mL. The ratio of F-actin to G-actin decreased after treatment, which corresponded to a change in fibroblast stiffness. The storage modulus (G′) and loss modulus (G″) of the skin equivalent were both lowered by red ginseng treatment. This result indicates that the viscoelasticity of the skin equivalent can be restored by red ginseng treatment. |
| Databáze: | OpenAIRE |
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