Synthesis, docking, and biological evaluation of novel 1-benzyl-4-(4-(R)-5-sulfonylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyrrolidin-2-ones as potential nootropic agents

Autor:	Anton P. Semenets, Marharyta M. Suleiman, Andrii I. Fedosov, Sergiy Yu Shtrygol, Ihnat O. Havrylov, Mariia V. Mishchenko, Sergiy M. Kovalenko, Victoriya A. Georgiyants, Lina O. Perekhoda
Rok vydání:	2022
Předmět:	Pharmacology Molecular Docking Simulation Structure-Activity Relationship Magnetic Resonance Spectroscopy Organic Chemistry Drug Discovery General Medicine Mass Spectrometry Nootropic Agents Pyrrolidinones Chromatography Liquid
Zdroj:	European journal of medicinal chemistry. 244
ISSN:	1768-3254
Popis:	In order to search for innovative nootropic agents, new 1-benzyl-4- (4- (R)-5-sulfonylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl) pyrrolidine-2-ones was synthesized by reacting benzylamine with itaconic acid to 1-benzyl-5-oxopyrrolidine-3-carboxylic acid, which was then subjected to hydrazinolysis followed by the addition of substituted isothiacyanate followed by cyclization of intermediate thiosemicarbazides. The structure and purity of the obtained substances were confirmed by elemental analysis
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084bc49be177943f91c8fd3455043532 https://pubmed.ncbi.nlm.nih.gov/36274278 Zobrazit plný text záznamu Full Text from ScienceDirect