Transporters and tubule crystals in the insect Malpighian tubule
Autor: | Michael F. Romero, Daniel R. Turin, Carmen J. Reynolds |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0106 biological sciences
0301 basic medicine media_common.quotation_subject Calcium oxalate chemistry.chemical_element Insect Calcium Malpighian Tubules Nephrolithiasis 010603 evolutionary biology 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound medicine Animals Ecology Evolution Behavior and Systematics media_common Kidney biology Calcium Oxalate fungi biology.organism_classification medicine.disease Cell biology Disease Models Animal 030104 developmental biology Tubule medicine.anatomical_structure Drosophila melanogaster chemistry Insect Science Kidney stones Function (biology) |
Zdroj: | Curr Opin Insect Sci |
Popis: | The insect renal (Malpighian) tubules are functionally homologous to the mammalian kidney. Accumulating evidence indicates that renal tubule crystals form in a manner similar to mammalian kidney stones. In Drosophila melanogaster, crystals can be induced by diet, toxic substances, or genetic mutations that reflect circumstances influencing or eliciting kidney stones in mammals. Incredibly, many mammalian proteins have distinct homologs in Drosophila, and the function of most homologs have been demonstrated to recapitulate their mammalian and human counterparts. Here, we discuss the present literature establishing Drosophila as a nephrolithiasis model. This insect model may be used to investigate and understand the etiology of kidney stone diseases, especially with regard to calcium oxalate, calcium phosphate and xanthine or urate crystallization. |
Databáze: | OpenAIRE |
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