Pituitary macroadenoma presenting as a nasal tumor: case report
| Autor: | Nivaldo Adolfo Silva Junior, Heraldo Mendes Garmes, Cristina Laguna Benetti-Pinto, Fabiano Reis, Guilherme Henrique Alves Vieira, Luciano de Souza Queiroz, Larissa Kaori Miura |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Nasal cavity
Adenoma Adult Pathology medicine.medical_specialty Pituitary gland Sphenoid Sinus Nose Neoplasms lcsh:Medicine Pituitary neoplasms Pituitary neoplasm Nose neoplasm Diagnosis Differential Pituitary adenoma Acromegaly medicine otorhinolaryngologic diseases Humans Neoplasm Invasiveness Pituitary Neoplasms Insulin-Like Growth Factor I Amenorrhea business.industry Human Growth Hormone lcsh:R General Medicine medicine.disease Magnetic Resonance Imaging Prolactin Sella turcica medicine.anatomical_structure Growth hormone-secreting pituitary adenoma Female Nasal Obstruction business Paranasal Sinus Neoplasms |
| Zdroj: | Sao Paulo Medical Journal v.132 n.6 2014 São Paulo medical journal Associação Paulista de Medicina instacron:APM São Paulo Medical Journal, Vol 132, Iss 6, Pp 377-381 |
| Popis: | CONTEXT: Pituitary macroadenomas are rare intracranial tumors. In a few cases, they may present aggressive behavior and invade the sphenoid sinus and nasal cavity, causing unusual symptoms. In this paper, we report an atypical case of pituitary adenoma presenting as a nasal mass.CASE REPORT: The patient was a 44-year-old woman who had had amenorrhea and galactorrhea for ten months, with associated nasal obstruction, macroglossia and acromegaly. Both growth hormone and prolactin levels were increased. Magnetic resonance imaging showed a large mass originating from the lower surface of the pituitary gland, associated with sella turcica erosion and tumor extension through the sphenoid sinus and nasal cavity. Histopathological analysis demonstrated a chromophobe pituitary adenoma with densely packed rounded epithelial cells, with some atypias and rare mitotic figures. There was no evidence of metastases.CONCLUSION: Macroadenoma invading the nasal cavity is a rare condition and few similar cases have been reported in the literature. This study contributes towards showing that tumor extension to the sphenoid sinus and nasopharynx needs to be considered and investigated in order to make an early diagnosis when atypical symptoms like nasal obstruction are present. |
| Databáze: | OpenAIRE |
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