Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects
| Autor: | Kamila Borowiec, Dominik Szwajgier, Ewa Baranowska-Wójcik |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030109 nutrition & dietetics Amyloid Aché Pharmacology Acetylcholinesterase Cinnamic acid In vitro language.human_language 03 medical and health sciences chemistry.chemical_compound Neurology chemistry Alzheimer Disease In vivo Hydroxybenzoates language Animals Humans Cholinesterase Inhibitors Neurology (clinical) Nootropic Agents Ex vivo Butyrylcholinesterase |
| Zdroj: | Current Alzheimer Research. 15:531-543 |
| ISSN: | 1567-2050 |
| Popis: | Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement. |
| Databáze: | OpenAIRE |
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