Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(ii) complexes

Autor:	Dmitry V. Gutsulyak, Richard J. Burford, Warren E. Piers, Javier Borau-Garcia
Rok vydání:	2015
Předmět:	inorganic chemicals Inorganic Chemistry Steric effects Nickel chemistry organic chemicals Organic chemistry chemistry.chemical_element Substrate (chemistry) Medicinal chemistry 3. Good health Catalysis Pincer movement
Zdroj:	Dalton Transactions. 44:12082-12085
ISSN:	1477-9234 1477-9226
DOI:	10.1039/c4dt03902e
Popis:	The (PCP)Ni-OH complexes (R = (i)Pr, (t)Bu, Cy) are effective catalyst precursors for the selective hydration of nitriles to the corresponding amides under relatively mild conditions (80 °C) and low catalyst loadings (0.05-0.5%). Substrate scope includes aliphatic, vinylic and aromatic nitriles, but substrates with protic groups poison the catalyst abruptly. The catalysts are effective because the electron rich nature of the PCP ligands and their steric bulk renders the hydroxo group labile.
Databáze:	OpenAIRE
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