Emulsions with alkyl polyglucosides as carriers for off-label topical spironolactone - safety and stability evaluation
| Autor: | Maja Cvetkovic, Dusan Ilic, Marija Tasic-Kostov |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject Administration Topical Pharmaceutical Science 02 engineering and technology Spironolactone urologic and male genital diseases Off-label use 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound Surface-Active Agents 0302 clinical medicine Glucosides Medicine Humans Acne Alkyl media_common Mineralocorticoid Receptor Antagonists Skin chemistry.chemical_classification business.industry General Medicine Off-Label Use 021001 nanoscience & nanotechnology medicine.disease Dermatology chemistry Emulsions 0210 nano-technology business |
| Zdroj: | Pharmaceutical development and technology. 26(3) |
| ISSN: | 1097-9867 |
| Popis: | Androgens play an important role in the pathogenesis of acne. Being an anti-androgen drug with many side effects, spironolactone has recently been used in dermatology as a topical therapy for acne. Off-label drug use in dermatology is common, although those drugs are basically available as compounded formulations; the choice of a proper vehicle is often neglected in that case. Alkyl polyglucosides (APGs) are a FDA certified class of polyethylene glycol (PEG)-free surfactants produced from the renewable resources. Following the preformulation tests, two different APG emulsifiers were used in this study to stabilize emulsions as carriers for topical spironolactone. Assessment of the physical stability of emulsions |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|