Adenomatoid tumours: a mucin histochemical and immunohistochemical study
| Autor: | M.J. Goddard, J.W. Grant |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Mesothelioma Pathology medicine.medical_specialty Histology Staining and Labeling biology Mucin Enolase Vimentin General Medicine Pathology and Forensic Medicine Staining Immunoenzyme Techniques Antigen Polyclonal antibodies Monoclonal biology.protein medicine Humans Immunohistochemistry Female |
| Zdroj: | Histopathology. 20:57-61 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1111/j.1365-2559.1992.tb00917.x |
| Popis: | We have examined 16 cases of adenomatoid tumour using a panel of monoclonal and polyclonal antibodies and also stained them for the presence of hyaluronidase-sensitive alcianophilic material. Fourteen cases expressed cytokeratins and a proportion of these also expressed S-100 protein, neuron-specific enolase, vimentin, and human milk fat globule protein 2. The same 14 cases also showed hyaluronidase-sensitive staining with alcian blue. No expression of factor VIII-related antigen was seen in these cases. We conclude that this provides further evidence of a mesothelial origin of these tumours. The remaining two cases did not express cytokeratins and no hyaluronidase-sensitive staining with alcian blue was seen. They did however express factor VIII-related antigen. Although they were morphologically indistinguishable from the other 14 cases, we suggest that they should be more properly regarded as angiomas. |
| Databáze: | OpenAIRE |
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