Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study
| Autor: | Hugo W. Huisman, Konstantin Kotliar, Nthai E. Ramoshaba, Aletta E. Schutte, Leandi Lammertyn, Wayne Smith |
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| Přispěvatelé: | 10062718 - Huisman, Hugo Willem, 20088310 - Lammertyn, Leandi, 10922180 - Schutte, Aletta Elisabeth, 22945717 - Smith, Wayne |
| Rok vydání: | 2020 |
| Předmět: |
Central retinal artery
medicine.medical_specialty Central retinal vein Ambulatory blood pressure Physiology Provocation test 030204 cardiovascular system & hematology Masked hypertension Retinal vessel calibers 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.artery Internal medicine Internal Medicine Medicine 030212 general & internal medicine Young adult Prospective cohort study Young age business.industry Retinal Retinal vessel dilation Masked Hypertension medicine.anatomical_structure chemistry Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Hypertension Research. 43:1231-1238 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1038/s41440-020-0487-0 |
| Popis: | Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20-30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R2 = 0.267, β = -0.097 (95% CI = -0.165; -0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life. |
| Databáze: | OpenAIRE |
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