Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma

Autor: Ayşe Ufuk, Terence Garner, Adam Stevens, Ayşe Latif
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cancers; Volume 14; Issue 5; Pages: 1298
Ufuk, A, Garner, T, Stevens, A & Latif, A 2022, ' Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma ', Cancers, vol. 14, no. 5, 1298 . https://doi.org/10.3390/cancers14051298
ISSN: 2072-6694
DOI: 10.3390/cancers14051298
Popis: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a five-year survival rate of Simple SummaryMonocarboxylate transporters (MCTs) carry a variety of substrates with MCT1-4 being well characterised and involved in proton-coupled transport of monocarboxylates (such as lactate) which can be used as metabolic fuel for cancer cells. Increased acidity of tumour microenvironment via MCTs favours remodelling of extracellular matrix (ECM) leading to desmoplasia associated with tumour metastasis and poor patient outcomes. Although MCT1-2/4 are upregulated in several cancers, their expression and role in pancreatic ductal adenocarcinoma desmoplasia is little understood. Here, we aimed to understand the role of MCTs in desmoplasia through their associations with ECM components. Our analysis using hypernetworks showed the presence of bidirectional associations of MCTs and ECMs, suggesting the presence of a causal relationship and the need to further investigate their functional associations. It confirms the role of MCTs in desmoplasia highlighting their importance as therapeutic targets alone or in combination with key ECM components to potentially improve patient outcomes.
Databáze: OpenAIRE
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