The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke
| Autor: | Marcin Gamdzyk, John H. Zhang, Sheng Tan, Jiping Tang, Cameron Lenahan, Ruiqing Kang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
microglia Inflammation Blood–brain barrier Article 03 medical and health sciences 0302 clinical medicine Immune system Dual role Humans Medicine Pharmacology (medical) Stroke Pharmacology polarization Microglia business.industry Endothelial Cells General Medicine medicine.disease Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure nervous system Neurology Blood-Brain Barrier inflammation Astrocytes cardiovascular system Neurology (clinical) medicine.symptom business Neuroscience Bbb permeability 030217 neurology & neurosurgery |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1570-159X |
| DOI: | 10.2174/1570159x18666200529150907 |
| Popis: | It is well-known that stroke is one of the leading causes of death and disability all over the world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of endothelial cells surrounded by astrocytes. Microglia, considered the long-living resident immune cells of the brain, play a vital role in BBB function. M1 microglia worsen BBB disruption, while M2 microglia assist in repairing BBB damage. Microglia can also directly interact with endothelial cells and affect BBB permeability. In this review, we are going to discuss the mechanisms responsible for the dual role of microglia in BBB dysfunction after stroke. |
| Databáze: | OpenAIRE |
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