Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report

Autor: Sonali Chaudhury, Ka Wah Chan, Kristin Page, Morton J. Cowan, Gregory A. Hale, Kimberly A. Kasow, Allistair Abraham, Elizabeth Thiel, Anne B. Warwick, Valerie I. Brown, Jeffery J. Auletta, Miguel Angel-Diaz, Amy K. Keating, Hisham Abdel-Azim, Baldeep Wirk, Farid Boulad, Carrie L. Kitko, Richard F. Olsson, Shahinaz M. Gadalla, Bruce M. Camitta, Heather R. Millard, Robert Peter Gale, Pooja Khandelwal, Margaret L. MacMillan, Adriana Seber, Angela R. Smith, Parinda A. Mehta
Rok vydání: 2017
Předmět:
Male
Oncology
Transplantation Conditioning
medicine.medical_treatment
Pediatric cancers
Hematopoietic stem cell transplantation
Regenerative Medicine
Neuroblastoma
0302 clinical medicine
Stem Cell Research - Nonembryonic - Human
Child
Autografts
Cancer
Pediatric
Hematology
Brain Neoplasms
Hematopoietic Stem Cell Transplantation
Allografts
surgical procedures
operative
Child
Preschool
030220 oncology & carcinogenesis
Female
Pediatric Research Initiative
medicine.medical_specialty
Adolescent
Childhood Leukemia
Pediatric Cancer
Calcineurin Inhibitors
Clinical Sciences
Immunology
Article
03 medical and health sciences
Rare Diseases
Clinical Research
Internal medicine
medicine
Humans
Preschool
Intensive care medicine
Retrospective Studies
Transplantation
business.industry
Infant
Stem Cell Research
medicine.disease
Pediatric cancer
Methotrexate
Orphan Drug
Bone transplantation
business
030215 immunology
Zdroj: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, vol 23, iss 8
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2017.04.018
Popis: This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric patients with cancer, 4408 undergoing allogeneic (allo) and3076 undergoing autologous (auto) HSCT in the United States between 2008 and 2014. In both settings, there was a greater proportion of boys (n = 4327; 57%), children < 10 years of age (n = 4412; 59%), whites (n = 5787; 77%), and children with a performance score ≥ 90% at HSCT (n = 6187; 83%). Leukemia was the most common indication for an allo-transplant (n = 4170; 94%), and among these, acute lymphoblastic leukemia in second complete remission (n = 829; 20%) and acute myeloid leukemia in first complete remission (n = 800; 19%) werethe most common. The most frequently used donor relation, stem cell sources, and HLA match were unrelated donor (n = 2933; 67%), bone marrow (n = 2378; 54%), and matched at 8/8 HLA antigens (n = 1098; 37%) respectively. Most allo-transplants used myeloablative conditioning (n = 4070; 92%) and calcineurin inhibitors and methotrexate (n = 2245; 51%) for acute graft-versus-host disease prophylaxis. Neuroblastoma was the most common primary neoplasm for an auto-transplant (n = 1338; 44%). Tandem auto-transplants for neuroblastoma declined after 2012 (40% in 2011, 25% in 2012, and 8% in 2014), whereas tandem auto-transplants increased for brain tumors (57% in 2008 and 77% in 2014). Allo-transplants from relatives other than HLA-identical siblings doubled between 2008 and 2014 (3% in 2008 and 6% in 2014). These trends will be monitored in future reports of transplant practices in the United States.
Databáze: OpenAIRE
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