Clinical significance of measuring reticulated platelets in infectious diseases
| Autor: | Ming-yue Song, Qin-hua Liu, Ruixiang Xia, Bai-xia Yang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Adolescent Observational Study Reticulated platelets Signs and symptoms 030204 cardiovascular system & hematology Communicable Diseases Sensitivity and Specificity reticulated platelet Gastroenterology Procalcitonin Body Temperature Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine White blood cell medicine Humans Clinical significance Young adult Aged Aged 80 and over Receiver operating characteristic Platelet Count business.industry Case-control study General Medicine Middle Aged infection C-Reactive Protein medicine.anatomical_structure Case-Control Studies 030220 oncology & carcinogenesis Female diagnostic value business Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000009424 |
| Popis: | This study aimed to explore the association between the percentage of reticulated platelets (RP%) and infection, and analyze the value of combined measurement of RP% with other inflammatory indicators in diagnosing infection. A total of 190 patients with signs and symptoms suspicious of infection were included in the infection group, and 70 healthy subjects with comparable percentages of gender and age were included in the control group. Peripheral white blood cell (WBC) count, percentage of neutrophils (N%), platelet count, C-reactive protein (CRP), procalcitonin (PCT), RP%, and axillary temperature were recorded. Dynamic changes in RP% with infection were measured to analyze the association between RP% and infection. The receiver operating characteristic curve was used to evaluate the value of each inflammatory indicator in diagnosing infection and analyze the diagnostic value of the combined adoption of multiple inflammatory indicators. RP% was significantly higher in the infection group than in the noninfection and control groups. The sensitivity and specificity for diagnosing infection were, respectively, 91.78% and 93.18% when RP% and CRP were used in combination, 90.41% and 90.90% when RP% and PCT were used in combination, and 100% and 100% when RP%, CRP, and PCT were used in combination. RP% changed dynamically with the progression of infection and recovered to lower than 5.5% at 2 to 7 days before the body temperature recovered to a normal level. The diagnostic value of RP% was the highest. A combined use with CRP/PCT could improve the sensitivity and specificity in the early diagnosis of infectious diseases. |
| Databáze: | OpenAIRE |
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