Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006
| Autor: | Udo Bode, Andreas Müller, Michael J. Lentze, Vanessa Ditt, Sebastian Völz, Arne Simon, Oliver Schildgen, Bernd Kupfer, Ramona Liza Tillmann, Dennis Klinkenberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Human Bocavirus Respiratory tract infection Hospitalized infants and children medicine.disease_cause Article Bocavirus Hospitals University Parvoviridae Infections Virology Germany Nasopharynx Prevalence Medicine Humans Prospective Studies Prospective cohort study Respiratory Tract Infections Respiratory tract infections biology business.industry Human bocavirus Infant Retrospective cohort study medicine.disease biology.organism_classification Hospitals Pediatric Pneumonia Infectious Diseases Croup Population Surveillance Norovirus Bronchitis Female Seasons business |
| Zdroj: | Journal of Clinical Virology |
| ISSN: | 1873-5967 1386-6532 |
| Popis: | Background Human Bocavirus (HBoV), a new species of the genus parvovirus newly detected in 2005, seems to be a worldwide distributed pathogen among children with respiratory tract infection (prevalence 2%–18%). Recently published retrospective studies and one prospective birth cohort study suggest that HBoV-primary infection occurs in infants. Methods Prospective single center study over one winter season (November 2005–May 2006) with hospitalized children without age restriction using PCR-based diagnostic methods. Results HBoV DNA was detected in 11 (2.8%) of 389 nasopharyngeal aspirates from symptomatic hospitalized children (median age 9.0 months; range: 3–17 months). RSV, HMPV, HCoV, and Influenza B were detected in 13.9% ( n = 54), 5.1% ( n = 20), 2.6% ( n = 10), and 1.8% ( n = 7), respectively. There was no influenza A DNA detected in any of the specimens. The clinical diagnoses were acute wheezing (bronchitis) in four patients, radiologically confirmed pneumonia in six patients (55%) and croup syndrome in one patient. In five to six patients with pneumonia, HBoV was the only pathogen detected. While no patient had to be mechanically ventilated, 73% needed oxygen supplementation. In four (36.4%) patients at least one other viral pathogen was found (plus RSV n = 3; 27.3%; Norovirus n = 1; 9.1%). Conclusion HBoV causes severe respiratory tract infections in infants and young children. Its role as a copathogen and many other open questions has to be defined in further prospective studies. |
| Databáze: | OpenAIRE |
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