Growth retardation and renal osteodystrophy in children with chronic renal failure
| Autor: | Elisabeth M Hodson, Pamela F. Shaw, Richard A. Evans, C. R. Dunstan, L. Paul Roy, Stanley Y. P. Wong, E Hills, Andrew R. Rosenberg |
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| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Bone disease Urology Renal function Disease urologic and male genital diseases Age Determination by Skeleton Internal medicine medicine Humans Renal osteodystrophy Child Growth Disorders Chronic Kidney Disease-Mineral and Bone Disorder business.industry Infant Histology Bone age medicine.disease Body Height Endocrinology Child Preschool Pediatrics Perinatology and Child Health Delayed skeletal maturation Etiology Kidney Failure Chronic Female business Glomerular Filtration Rate |
| Zdroj: | The Journal of Pediatrics. 103:735-740 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(83)80467-3 |
| Popis: | Height, expressed as standard deviation scores for chronological age and for bone age, was studied in relation to glomerular filtration rate, bone age delay, and bone histology in 47 children with chronic renal disease and GFR less than 80 ml/min/1.73 m2. In multiple regression in all 47 patients, only GFR and bone age delay significantly affected height; 40% of children were short (height standard deviation score less than -2) for chronological age, and 9% were short for bone age. Renal osteodystrophy, which only occurred at GFR less than 30 ml/min/1.73 m2, significantly affected height only in children with congenital renal disease and GFR less than 20 ml/min/1.73 m2. Although radiological and biochemical changes of renal osteodystrophy were seen more often in short children, histological bone disease occurred just as frequently in tall children as in short children. Thus much of the observed height retardation in chronic renal failure is associated with delayed skeletal maturation. In addition, although severe renal osteodystrophy may contribute to growth retardation in advanced renal failure, our data suggest that milder degrees of bone disease evident only on histological study cannot be implicated in the etiology of growth failure in chronic renal impairment. |
| Databáze: | OpenAIRE |
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