Relation of Retinal and Serum Lutein and Zeaxanthin to White Matter Integrity in Older Adults: A Diffusion Tensor Imaging Study
| Autor: | Catherine M Mewborn, Billy R. Hammond, Douglas P. Terry, Lisa M. Renzi-Hammond, L. Stephen Miller |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent Uncinate fasciculus Neuropsychological Tests Corpus callosum White matter Young Adult 03 medical and health sciences Cognition 0302 clinical medicine Blood serum Neuroimaging Zeaxanthins Ophthalmology medicine Humans Cingulum (brain) Aged business.industry Lutein Fornix Brain General Medicine White Matter Psychiatry and Mental health Clinical Psychology Diffusion Tensor Imaging 030104 developmental biology Neuropsychology and Physiological Psychology medicine.anatomical_structure Female business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Archives of Clinical Neuropsychology. 33:861-874 |
| ISSN: | 1873-5843 |
| DOI: | 10.1093/acn/acx109 |
| Popis: | Objective Lutein (L) and zeaxanthin (Z) are phytonutrients that accumulate in human brain tissue and positively impact cognition. Given their antioxidant and anti-inflammatory properties and their role in stabilizing cell membranes, L&Z may relate to measures of white matter integrity (WMI). Method The current study tested the relation of retinal (macular pigment optical density/MPOD) and blood serum concentrations of L&Z to WMI in community-dwelling older adults (n = 54) using diffusion tensor imaging (DTI). Younger adults (n = 38) were recruited as a control group to confirm age-related changes in WMI. A priori analyses focused on four regions of interest (ROIs-genu of the corpus callosum, cingulum, fornix, and uncinate fasciculus). Exploratory whole-brain analyses were also conducted. Results Consistent with previous literature, age group (young vs. old) negatively predicted WMI globally, in the genu, cingulum, and fornix (p < .001). ROI analysis in the older adult sample showed relations of MPOD and serum L&Z to better WMI in the uncinate fasciculus and cingulum (p < .05, FWE-corrected). Whole-brain analysis suggested associations between L&Z and WMI in both anterior white matter tracts vulnerable to age-related decline and posterior tracts (p < .01, uncorrected). Conclusions The current study is among the first to use neuroimaging to measure the relation of L&Z to brain structure in vivo. Results confirm previous findings that L&Z influence white matter integrity, particularly in regions vulnerable to age-related decline. The current study contributes to a growing literature investigating the relationship between diet and neural integrity by identifying white matter tracts that may be associated with modifiable dietary factors in older adults. |
| Databáze: | OpenAIRE |
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