SOME PHARMACOLOGICAL PROPERTIES OF MUREXINE (UROCANOYLCHOLINE)

Autor:	V. P. Whittaker, M. J. Keyl
Rok vydání:	1958
Předmět:	Bromides Chemistry Stereochemistry Imidazoles Depolarization Articles General Medicine Choline Rats Blockade Ganglion Dogs medicine.anatomical_structure Felis Cats medicine Biophysics Animals Gracilis muscle
Zdroj:	British Journal of Pharmacology and Chemotherapy. 13:103-106
ISSN:	0366-0826
DOI:	10.1111/j.1476-5381.1958.tb00200.x
Popis:	Murexine (urocanoylcholine, [2-β-imidazol-4(5)-ylacryloyloxyethyl] trimethylammonium bromide) has been shown to possess ganglion stimulating and neuromuscular blocking actions in cat, dog and rat. The blockade has been shown to be of the depolarizing type both on the basis of the resemblance of the pharmacological properties of the substance to that of known depolarizing blocking agents, and also directly by recording the depolarization produced in the endplate region of the gracilis muscle of the rat.
Databáze:	OpenAIRE
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