Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
| Autor: | Russell G. Kerr, Amber C. Kohl |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
food.ingredient
Stereochemistry Pharmaceutical Science elisabethatriene Biology Pseudopterogorgia Biosynthesis 010402 general chemistry 01 natural sciences Cyclase Article diterpene chemistry.chemical_compound food Geranylgeranyl diphosphate Drug Discovery pseudopterosin lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Pseudopterogorgia elisabethae 010405 organic chemistry Aromatization Elisabethatriene Pseudopterosins Combinatorial chemistry 0104 chemical sciences lcsh:Biology (General) chemistry Diterpene |
| Zdroj: | Marine Drugs, Vol 1, Iss 1, Pp 54-65 (2003) Marine Drugs Marine Drugs; Volume 1; Issue 1; Pages: 54-65 |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md101054 |
| Popis: | Putative precursors in pseudopterosin biosynthesis, the hydrocarbons isoelisabethatriene (10) and erogorgiaene (11), have been identified from an extract of Pseudopterogorgia elisabethae collected in the Florida Keys. Biosynthetic experiments designed to test the utilization of these compounds in pseudopterosin production revealed that erogorgiaene is transformed to pseudopterosins A-D. Together with our previous data, it is now apparent that early steps in pseudopterosin biosynthesis involve the cyclization of geranylgeranyl diphosphate to elisabethatriene followed by the dehydrogenation and aromatization to erogorgiaene. |
| Databáze: | OpenAIRE |
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