Electro-physiology Models of Cells with Spherical Geometry with Non-conducting Center
| Autor: | Jiamu Jiang, Paul A. Smith, Mark C. W. van Rossum |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Ionic currents
Materials science Voltage clamp General Mathematics Immunology Shell (structure) 030209 endocrinology & metabolism Cable equation Models Biological General Biochemistry Genetics and Molecular Biology Spherical geometry 03 medical and health sciences 0302 clinical medicine Adipocytes Cylinder General Environmental Science Pharmacology Mathematical models General Neuroscience Mathematical Concepts Mechanics Electrophysiological Phenomena Flow (mathematics) Computational Theory and Mathematics Original Article Cable theory Current (fluid) General Agricultural and Biological Sciences 030217 neurology & neurosurgery Voltage |
| Zdroj: | Bulletin of Mathematical Biology |
| ISSN: | 0092-8240 1522-9602 |
| Popis: | We study the flow of electrical currents in spherical cells with a non-conducting core, so that current flow is restricted to a thin shell below the cell’s membrane. Examples of such cells are fat storing cells (adipocytes). We derive the relation between current and voltage in the passive regime and examine the conditions under which the cell is electro-tonically compact. We compare our results to the well-studied case of electrical current flow in cylinder structures, such as neurons, described by the cable equation. In contrast to the cable, we find that for the sphere geometry (1) the voltage profile across the cell depends critically on the electrode geometry, and (2) the charging and discharging can be much faster than the membrane time constant; however, (3) voltage clamp experiments will incur similar distortion as in the cable case. We discuss the relevance for adipocyte function and experimental electro-physiology. |
| Databáze: | OpenAIRE |
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