Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study
| Autor: | Yoshiaki Takahashi, Yumiko Nakano, Yasuyuki Ohta, Setsuko Ueno, Yoshihide Sunada, Yosuke Wakutani, Nobutoshi Morimoto, Kentaro Deguchi, Nozomi Hishikawa, Markus Graf Matuschka Von Greiffenclau, Katsushi Taomoto, Haruhiko Inufusa, Koji Abe, Namiko Matsumoto, Ryuta Morihara, Yumiko Kutoku, Emi Nomura, Koh Tadokoro, Satoko Kawano, Ryo Sasaki, Toru Yamashita, Mami Takemoto, Yasuto Higashi, Yoshiki Takao, Yasuhiro Manabe, Fukka You, Toshikazu Yoshikawa |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Activities of daily living Glutamine Dietary supplement Ascorbic Acid Placebo Antioxidants law.invention Double blind 03 medical and health sciences 0302 clinical medicine Cognition Randomized controlled trial Double-Blind Method law Internal medicine Activities of Daily Living medicine Dementia Humans Cognitive Dysfunction Prospective Studies Cognitive impairment Pathological Aged Aged 80 and over business.industry General Neuroscience General Medicine medicine.disease Mental Status and Dementia Tests Psychiatry and Mental health Clinical Psychology 030104 developmental biology Treatment Outcome Dietary Supplements Cystine Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease : JAD. 71(3) |
| ISSN: | 1875-8908 |
| Popis: | Oxidative stress is part of the entire pathological process that underlies the development of Alzheimer's disease (AD), including the mild cognitive impairment (MCI) stage. Twendee X (TwX) is a supplement containing a strong antioxidative mix of eight antioxidants, which has been shown to have a clinical and therapeutic benefit in AD model mice. Here, we conducted a multicenter, randomized, double-blind, and placebo-controlled prospective interventional study to evaluate the efficacy of TwX in mitigating MCI. The primary outcomes were differences in Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-revised (HDS-R) scores between baseline and six months for placebo and TwX groups. Seventy-eight subjects with MCI were randomized into placebo (n = 37) and TwX (n = 41) groups. MMSE scores at six months differed significantly between the TwX and placebo groups (p = 0.018), and HDS-R scores for the TwX group exhibited a significant improvement at six months relative to baseline (p = 0.025). The TwX group did not show any change in affective or activities of daily living scores at six months. The present study indicates that strong antioxidative supplement TwX is clinical beneficial for cognitive function in subjects with MCI. |
| Databáze: | OpenAIRE |
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