Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia
| Autor: | Maude E. Phipps, Boon Peng Hoh, Yan Lu, Thuhairah Hasrah Abdul Rahman, Yushimah Yunus, Rick Twee-Hee Ong, Farhang Aghakhanian, Chee Wei Yew, Xiaoji Wang, Yik Ying Teo, Mohammad Zahirul Hoque, Christopher Lok Yung Voo, Jong Bhak, Dongsheng Lu, Shuhua Xu, Lai-Ping Wong, Lian Deng, Subbiah Vijay Kumar, Siti Shuhada Mokhtar |
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| Rok vydání: | 2018 |
| Předmět: |
Gene Flow
0301 basic medicine Neanderthal Human Migration Population Introgression DNA Mitochondrial Polymorphism Single Nucleotide Gene flow 03 medical and health sciences Borneo biology.animal parasitic diseases Genetics Humans East Asia education Denisovan Asia Southeastern Genetics (clinical) Ancestor education.field_of_study biology Genome Human Human migration business.industry Ecology Malaysia Genetic Variation Genomics biology.organism_classification Genetics Population 030104 developmental biology business |
| Zdroj: | Human Genetics. 137:161-173 |
| ISSN: | 1432-1203 0340-6717 |
| Popis: | Southeast Asia (SEA) is enriched with a complex history of peopling. Malaysia, which is located at the crossroads of SEA, has been recognized as one of the hubs for early human migration. To unravel the genomic complexity of the native inhabitants of Malaysia, we sequenced 12 samples from 3 indigenous populations from Peninsular Malaysia and 4 native populations from North Borneo to a high coverage of 28-37×. We showed that the Negritos from Peninsular Malaysia shared a common ancestor with the East Asians, but exhibited some level of gene flow from South Asia, while the North Borneo populations exhibited closer genetic affinity towards East Asians than the Malays. The analysis of time of divergence suggested that ancestors of Negrito were the earliest settlers in the Malay Peninsula, whom first separated from the Papuans ~ 50-33 thousand years ago (kya), followed by East Asian (~ 40-15 kya), while the divergence time frame between North Borneo and East Asia populations predates the Austronesian expansion period implies a possible pre-Neolithic colonization. Substantial Neanderthal ancestry was confirmed in our genomes, as was observed in other East Asians. However, no significant difference was observed, in terms of the proportion of Denisovan gene flow into these native inhabitants from Malaysia. Judging from the similar amount of introgression in the Southeast Asians and East Asians, our findings suggest that the Denisovan gene flow may have occurred before the divergence of these populations and that the shared similarities are likely an ancestral component. |
| Databáze: | OpenAIRE |
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