Interrelationship between the functional state of the central nervous system and lipid peroxidation level in brain following craniocerebral trauma
| Autor: | Promyslov Ms, Demchuk Ml |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Central Nervous System
Male medicine.medical_specialty Antioxidant medicine.medical_treatment Central nervous system Poison control Stimulation Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation chemistry.chemical_compound Chinchilla Internal medicine medicine Animals Hypnotics and Sedatives Amphetamine Molecular Biology Brain Chemistry Behavior Animal business.industry General Neuroscience Piracetam Neuroprotective Agents Endocrinology medicine.anatomical_structure chemistry Brain Injuries Phenobarbital Anesthesia Central Nervous System Stimulants Lipid Peroxidation Rabbits Neurology (clinical) business medicine.drug |
| Zdroj: | Molecular and Chemical Neuropathology. 25:69-80 |
| ISSN: | 1044-7393 |
| DOI: | 10.1007/bf02815087 |
| Popis: | The interrelationship between the functional state of the CNS and brain metabolism was studied in animals following craniocerebral trauma. Lipid peroxidation and antioxidant activity of rabbit brain were investigated a day after craniocerebral trauma. An increase in conjugated dienes, TBA-reactive products (TBARP), and fluorescent Schiff bases (SchB), and a sharp decrease in antioxidant activity in all brain regions investigated were established. The possibility of regulation of the disturbed processes by artificial alteration of the functional state of the CNS was shown. It was found that the day after stimulation of injured brain by amphetamine (phenamin) or piracetam, the values of lipid peroxidation and antioxidant activity came to the same levels as for controls. On the contrary, the depression of the CNS by phenobarbital (luminal) was not accompanied by such positive reactions. The stimulants did not possess antioxidant activity in vitro experiments on a model system. Thus, it was shown that following craniocerebral trauma, the lipid peroxidation process can be regulated by modification of the functional state of the CNS alone without special antioxidant therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink