Patterns of Infection in Patients With Myelodysplastic Syndromes and Acute Myeloid Leukemia Receiving Azacitidine as Salvage Therapy. Implications for Primary Antifungal Prophylaxis
| Autor: | Jose F Falantes, Maria Luz Martino, Francisco J. Márquez-Malaver, Rocío Parody, Isabel Montero, José González, Cristina Calderón, Ildefonso Espigado, José A. Pérez-Simón, Manuela Aguilar-Guisado, Almudena Martín-Peña |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty Antifungal Agents Myeloid Azacitidine Salvage therapy Aspergillosis hemic and lymphatic diseases Internal medicine medicine Humans Intensive care medicine Aged Retrospective Studies Aged 80 and over Salvage Therapy business.industry Incidence Myelodysplastic syndromes Incidence (epidemiology) Myeloid leukemia Hematology Middle Aged medicine.disease Leukemia Myeloid Acute medicine.anatomical_structure Oncology Myelodysplastic Syndromes Cohort business medicine.drug |
| Zdroj: | Clinical Lymphoma Myeloma and Leukemia. 14:80-86 |
| ISSN: | 2152-2650 |
| DOI: | 10.1016/j.clml.2013.09.014 |
| Popis: | Incidence, etiology, and outcome of infectious episodes in patients with myeloid neoplasms receiving azacitidine are uncertain, with no prospective data available in this group of patients. The aim of the current study was to analyze the incidence and factors related to the probability of infection in a cohort of patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) treated with azacitidine who did not receive any type of antimicrobial prophylaxis. Significantly, the group of patients who received prior intensive chemotherapy had more infectious episodes (P = 10(-4)), and particularly, invasive aspergillosis (P = .015), than patients who received frontline azacitidine. Primary antifungal prophylaxis might be recommended in MDS and AML patients receiving azacitidine as salvage therapy after intensive regimens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect