Development of the follicular basement membrane during human gametogenesis and early folliculogenesis
| Autor: | A. Marijne Heeren, Liesbeth van Iperen, Frans M. Helmerhorst, Maria Gomes Fernandes, Daniëlle B Klootwijk, Matthias S Roost, L. A. Louwe, Ana de Melo Bernardo, Susana M. Chuva de Sousa Lopes, Lucette A. J. van der Westerlaken, Carina G. J. M. Hilders |
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| Přispěvatelé: | Neurology, Obstetrics and gynaecology, CCA - Oncogenesis |
| Rok vydání: | 2015 |
| Předmět: |
Male
IV COLLAGEN Adult ovary Basement Membrane Gametogenesis Extracellular matrix 0302 clinical medicine Ovarian Follicle Laminin Testis Medicine and Health Sciences CHAINS HUMAN-FETAL OVARY 0303 health sciences 030219 obstetrics & reproductive medicine GRANULOSA-CELLS Cell biology medicine.anatomical_structure Female Folliculogenesis Germ cell Research Article Human EXPRESSION Collagen Type IV medicine.medical_specialty Ovarian Cortex FIBRONECTIN Biology 03 medical and health sciences Internal medicine EXTRACELLULAR-MATRIX medicine Germ cells Humans Ovarian follicle Gonads 030304 developmental biology Basement membrane Follicles HUMAN TESTES Ovary DEVELOPING OVARIAN-FOLLICLE LAMININ Fibronectins Fibronectin Endocrinology biology.protein Developmental Biology |
| Zdroj: | BMC developmental biology, 15(1):4. BioMed Central BMC Developmental Biology BMC DEVELOPMENTAL BIOLOGY BMC Developmental Biology, 15 Heeren, A M, van Iperen, L, Klootwijk, D B, Bernardo, A D, Roost, M S, Fernandes, M M G, Louwe, L A, Hilders, C G, Helmerhorst, F M, van der Westerlaken, L A J & Lopes, S M C D 2015, ' Development of the follicular basement membrane during human gametogenesis and early folliculogenesis ', BMC Developmental Biology, vol. 15, 4 . https://doi.org/10.1186/s12861-015-0054-0 BMC Developmental Biology, 15:4. BioMed Central |
| ISSN: | 1471-213X |
| Popis: | Background In society, there is a clear need to improve the success rate of techniques to restore fertility. Therefore a deeper knowledge of the dynamics of the complex molecular environment that regulates human gametogenesis and (early) folliculogenesis in vivo is necessary. Here, we have studied these processes focusing on the formation of the follicular basement membrane (BM) in vivo. Results The distribution of the main components of the extracellular matrix (ECM) collagen IV, laminin and fibronectin by week 10 of gestation (W10) in the ovarian cortex revealed the existence of ovarian cords and of a distinct mesenchymal compartment, resembling the organization in the male gonads. By W17, the first primordial follicles were assembled individually in that (cortical) mesenchymal compartment and were already encapsulated by a BM of collagen IV and laminin, but not fibronectin. In adults, in the primary and secondary follicles, collagen IV, laminin and to a lesser extent fibronectin were prominent in the follicular BM. Conclusions The ECM-molecular niche compartimentalizes the female gonads from the time of germ cell colonization until adulthood. This knowledge may contribute to improve methods to recreate the environment needed for successful folliculogenesis in vitro and that would benefit a large number of infertility patients. Electronic supplementary material The online version of this article (doi:10.1186/s12861-015-0054-0) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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