Angiotensin-Converting Enzyme Polymorphism and the Risk of Coronary Heart Disease in the Saudi Male Population
| Autor: | Nduna Dzimiri, Azadali Moorji, Chona Basco, Brian F. Meyer |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Population Saudi Arabia Blood Donors Coronary Disease Peptidyl-Dipeptidase A Polymerase Chain Reaction Pathology and Forensic Medicine Angina Coronary artery disease Risk Factors Internal medicine Diabetes mellitus Odds Ratio medicine Humans education Sequence Deletion education.field_of_study Polymorphism Genetic biology Vascular disease Angiotensin-converting enzyme General Medicine medicine.disease Introns Medical Laboratory Technology Endocrinology Case-Control Studies DNA Transposable Elements biology.protein Gene polymorphism |
| Zdroj: | Archives of Pathology & Laboratory Medicine. 124:531-534 |
| ISSN: | 1543-2165 0003-9985 |
| DOI: | 10.5858/2000-124-0531-acepat |
| Popis: | Objective.—To determine the relevance of angiotensin I–converting enzyme (ACE) gene polymorphism for coronary artery disease (CAD) in the Saudi population. Methods and Results.—DNA of 84 male Saudi patients with established CAD, 36 male controls who underwent angiography, and 327 healthy Saudi male blood donors was amplified by polymerase chain reaction, using oligonucleotide primers flanking the insertion (I)/deletion (D) sites in the polymorphic region of intron 16 of the ACE gene. Polymerase chain reaction amplification resulted in 490-bp (II), 190-bp (DD), or 490- and 190-bp (ID) fragments. The genotype II distribution was 16.7% in the control group, 7.3% in the blood donor group, and 7.2% in the patients with CAD, and the distribution for DD was 58.3%, 47.1%, and 41.0%, respectively. Notably, 61.9% (P < .0001) of CAD patients presented with angina on admission, and 52.4% had diabetes mellitus. Conclusions.—The results show no increased risk of CAD in association with either the II or DD genotypes in the Saudi population. However, further investigation of genotype II as a predictor for atherosclerosis rather than increased risk of coronary heart disease may be indicated. |
| Databáze: | OpenAIRE |
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