[Effectiveness of Topical NSAIDs in a Gastric Cancer Patient with Bone Metastasis Pain during Therapy with Opioids and Oral NSAIDs]
| Autor: | Tamaki Watanabe, Kunihisa Miura, Shigekazu Watanabe, Nobuhiro Yasuno, Kazutoshi Terayama, Mayumi Hamana, Kazuki Ohta, Masao Tsuchiya, Hiromi Enomoto |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Administration Topical Pharmaceutical Science Administration Oral Bone Neoplasms Fentanyl Stomach Neoplasms Internal medicine Activities of Daily Living Medicine Humans Aged Pharmacology business.industry Anti-Inflammatory Agents Non-Steroidal Bone metastasis Cancer Loxoprofen Cancer Pain medicine.disease digestive system diseases Analgesics Opioid Denosumab Treatment Outcome Celecoxib Drug Therapy Combination Cancer pain business Felbinac medicine.drug |
| Zdroj: | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 140(8) |
| ISSN: | 1347-5231 |
| Popis: | Cancer patients often suffer from severe pain related to bone metastasis. We encountered a patient in whom the addition of topical non-steroidal anti-inflammatory drugs (NSAIDs) for persistent pain related to bone metastasis during therapy with opioids and oral NSAIDs reduced pain, improving activities of daily living (ADL). Fentanyl patches, celecoxib, denosumab, and topical NSAIDs (loxoprofen tape, felbinac) were administered to a 72-year-old patient with gastric cancer and pain related to bone metastasis. Pain control was favorable, with a numerical rating scale (NRS) score of 2 and Japanese version Support Team Assessment Schedule (STAS-J) score of 1. Intervention by pharmacists for the use of topical NSAIDs decreased both the NRS and STAS-J scores to zero, improving ADL. The results suggest that topical NSAIDs relieve bone-metastasis-related pain, improving ADL. When bone-metastasis-related pain is localized, the prescription of topical NSAIDs should be considered, and positive intervention by pharmacists regarding their usage should be promoted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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