Composition of polysaccharides and radiosensitizing activity of native and sulfated laminarans from the Tаuуа basicrassa Kloczc. et Krupn
| Autor: | Vladimir V. Isakov, Tatiana N. Zvyagintseva, Roza V. Usoltseva, Stanislav D. Anastyuk, Tatiana N. Krupnova, Natalia M. Shevchenko, Svetlana P. Ermakova, Pavel A. Zadorozhny, Nikolai V. Zvyagintsev |
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| Rok vydání: | 2020 |
| Předmět: |
Radiation-Sensitizing Agents
Polymers and Plastics Fucogalactan Antineoplastic Agents 02 engineering and technology Phaeophyta 010402 general chemistry Polysaccharide 01 natural sciences Fucose chemistry.chemical_compound Sulfation Polysaccharides Tumor Cells Cultured Materials Chemistry Humans Sulfate Glucans chemistry.chemical_classification Sulfates Fucoidan X-Rays Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Biochemistry Galactose Colonic Neoplasms Composition (visual arts) 0210 nano-technology |
| Zdroj: | Carbohydrate Polymers. 250:116921 |
| ISSN: | 0144-8617 |
| Popis: | Polysaccharide fractions of alginate, laminarans and fucoidans were obtained from the brown alga Tauya basicrassa. Yields of alginate and laminarans were large (19.7 % and 5.62 %, respectively), whereas the content of fucoidans (0.52 %) was not significant. Alginate and laminarans had typical structures for those substances. Fucoidans were low- and medium-sulfated heterogeneous polysaccharides. The fucoidan fraction 1TbF1 was sulfated fucogalactan containing a backbone from 1,6-linked residues of β- d -galactopyranose with branches at C3 and C4, terminal fucose and galactose residues and fragments from 1,3-; 1,4-; and 1,2-fucose residues. Sulfate groups were found at positions 2 and 4 of fucose, and positions 2, 3 and 4 of galactose residues. Laminaran 2TbL was subjected to a sulfation to obtain the derivative 2TbLS with partial sulfation (46 %) at C2, C4 and C6. It was shown that 2TbL and 2TbLS inhibited colony formation of sensitize-tested colon cancer cells HT-29 and HCT-116 to X-ray radiation. |
| Databáze: | OpenAIRE |
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