Investigation of the relationship between chronic montelukast treatment, asthma and depression-like behavior in mice
| Autor: | Turgut Emrah Bozkurt, Emirhan Nemutlu, Gokcen Telli, Sevgen Onder, Banu Cahide Tel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research neuropsychiatric side-effects Inflammation Pharmacology Open field 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) immune system diseases medicine Forced swim Montelukast Depression (differential diagnoses) forced swim test Asthma biology business.industry ovalbumin General Medicine Articles asthma medicine.disease respiratory tract diseases Ovalbumin 030104 developmental biology 030220 oncology & carcinogenesis montelukast depression biology.protein medicine.symptom business hormones hormone substitutes and hormone antagonists medicine.drug Behavioural despair test |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | In 2008, the Food and Drug Administration of the US issued a warning about the neuropsychiatric side effects of montelukast. Previous clinical studies on montelukast have reported conflicting results and, to the best of our knowledge, no experimental studies concerning these side effects had been conducted. In the current study, the effect of montelukast on depression-like behavior in an ovalbumin (OVA)-induced mouse model was investigated. A total of 3 OVA challenges were applied at 2 week intervals for the persistence of asthma. Depression-like behavior was assessed using forced swim tests following each challenge and locomotor activities were evaluated using open field tests. At the end of the current study, plasma montelukast concentrations were measured and the development of asthma and effect of montelukast treatment were histopathologically examined. Inflammation scores that were increased in the OVA mice following all challenges were indicated to be reduced by montelukast treatment. The immobility time of mice increased beginning with the first challenge and this was also reduced by montelukast treatment. Montelukast administration to the control mice did not alter immobility times. Moreover, motor activity of the OVA and montelukast-treated mice were not altered. The results indicated there was no association between chronic montelukast treatment and depression. Furthermore, the chronic administration of montelukast to non-asthmatic mice did not increase immobility. However, depressive behavior increased at all time points in the OVA mice. These results indicated that chronic montelukast treatment is not associated with depression-like behavior and confirmed the association between asthma and depression. Further studies are required to provide an improved understanding of the neuropsychiatric side effects of montelukast. |
| Databáze: | OpenAIRE |
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