Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis
| Autor: | Göran Stenman, Jeanne M. Meis-Kindblom, Lars-Gunnar Kindblom, Anabel Peydro-Mellquist, Helene Sjögren, E. Röijer, Pierre Åman |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Fibrosarcoma Soft Tissue Neoplasms Round Cell Liposarcoma Liposarcoma Biology Pleomorphic Liposarcoma Pathology and Forensic Medicine Diagnosis Differential Cytogenetics Chondroid lipoma medicine Humans neoplasms Molecular Biology In Situ Hybridization Fluorescence Aged DNA Primers Aged 80 and over Myxoid liposarcoma Reverse Transcriptase Polymerase Chain Reaction Myxofibrosarcoma DNA Neoplasm Cell Biology General Medicine Middle Aged Intramuscular Myxoma Lipoma medicine.disease Liposarcoma Myxoid body regions Blotting Southern Karyotyping Female Myxoma |
| Zdroj: | Virchows Archiv. 439:141-151 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s004280100423 |
| Popis: | Liposarcoma is one of the most common sarcomas of adults. Its differential diagnosis and accurate subclassification are often problematic; the latter is also important with regard to appropriate treatment and prognosis. We studied a series of 23 liposarcomas that had unusual or previously undescribed features and 10 liposarcoma simulators and correlated the morphologic, cytogenetic, and molecular genetic findings. We found that use of cytogenetic-molecular genetic techniques aids in the distinction between myxoid-round cell liposarcoma and their simulators, chondroid lipoma, myxoid spindle cell-pleomorphic lipoma, cellular intramuscular myxoma, and myxofibrosarcoma. Poorly differentiated forms of round cell liposarcoma lacking morphologic evidence of lipogenesis can also be diagnosed using these techniques; however, the techniques do not aid in distinguishing low-grade myxoid from high-grade round cell liposarcomas. This study also shows that retroperitoneal liposarcomas with myxoid liposarcoma-like zones are part of the morphologic spectrum of well-differentiated-dedifferentiated liposarcoma rather than true myxoid liposarcomas. Perhaps most importantly, our results provide the first molecular genetic evidence that true mixed liposarcomas (mixed well-differentiated and myxoid liposarcoma) do indeed exist. They also unequivocally demonstrate the existence of small, round cell variants of pleomorphic liposarcoma that closely simulate myxoid-round cell liposarcoma. |
| Databáze: | OpenAIRE |
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