Outcome prediction after moderate and severe traumatic brain injury
| Autor: | Marek Majdan, Thomas Van Essen, Daniel Kondziella, Juan Sahuquillo, Oliver Sakowitz, Joukje Van der Naalt, Mathieu Van der Jagt, Ana M Castaño-Leon, Riikka Takala, Matti Pirinen, Thijs Vande Vyvere, Giuseppe Citerio, Rahul Raj, Jussi Posti, Renán Sánchez-Porras, Andreea Rădoi, Peter Hutchinson, Sandra Rossi, Pedro Gomez, Virginia Newcombe, William Stewart, Jonathan Coles, Frederick Zeiler, Aarno Palotie, Diederik Dippel, Arminas Ragauskas |
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| Přispěvatelé: | Dijkland, S. A., Helmrich, I. R. A. R., Nieboer, D., Van Der Jagt, M., Dippel, D. W. J., Menon, D. K., Stocchetti, N., Maas, A. I. R., Lingsma, H. F., Steyerberg E. W., (CENTER-TBI Participants and Investigators), Beretta, Luigi, Dijkland, S, Helmrich, I, Nieboer, D, Van Der Jagt, M, Dippel, D, Menon, D, Stocchetti, N, Maas, A, Lingsma, H, Steyerberg, E, Citerio, G, Public Health, Intensive Care, Neurology, Molecular Neuroscience and Ageing Research (MOLAR), CENTER-TBI Participants Investigators |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Neurologi Traumatic brain injury Crash Context (language use) Analysis of clinical trials 03 medical and health sciences 0302 clinical medicine external validation Brain Injuries Traumatic clinical prediction model Medicine Humans Models Statistical Receiver operating characteristic business.industry traumatic brain injury Head injury Recovery of Function medicine.disease 3. Good health Europe Neurology Emergency medicine Cohort outcome Human medicine Neurology (clinical) prognosis 0305 other medical science business 030217 neurology & neurosurgery prognosi Cohort study |
| Zdroj: | Journal of Neurotrauma, 38(10), 1377-1388. MARY ANN LIEBERT, INC Journal of Neurotrauma Journal of Neurotrauma, 38(10), 1377-1388. Mary Ann Liebert Inc. Journal of neurotrauma |
| ISSN: | 0897-7151 1557-9042 |
| Popis: | The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a contemporary cohort of patients across Europe. The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) core study is a prospective, observational cohort study in patients presenting with TBI and an indication for brain computed tomography. The CENTER-TBI core cohort consists of 4509 TBI patients available for analyses from 59 centers in 18 countries across Europe and Israel. The IMPACT validation cohort included 1173 patients with GCS = 14, and 6-month Glasgow Outcome Scale-Extended (GOSE) available. The CRASH validation cohort contained 1742 patients with GCS = 16, and 14-day mortality or 6-month GOSE available. Performance of the three IMPACT and two CRASH model variants was assessed with discrimination (area under the receiver operating characteristic curve; AUC) and calibration (comparison of observed vs. predicted outcome rates). For IMPACT, model discrimination was good, with AUCs ranging between 0.77 and 0.85 in 1173 patients and between 0.80 and 0.88 in the broader CRASH selection (n = 1742). For CRASH, AUCs ranged between 0.82 and 0.88 in 1742 patients and between 0.66 and 0.80 in the stricter IMPACT selection (n = 1173). Calibration of the IMPACT and CRASH models was generally moderate, with calibration-in-the-large and calibration slopes ranging between -2.02 and 0.61 and between 0.48 and 1.39, respectively. The IMPACT and CRASH models adequately identify patients at high risk for mortality or unfavorable outcome, which supports their use in research settings and for benchmarking in the context of quality-of-care assessment. |
| Databáze: | OpenAIRE |
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