Functional circuits and signal processing in the enteric nervous system
| Autor: | Candice Fung, Pieter Vanden Berghe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
ENTEROENDOCRINE CELLS
Enteroendocrine cell Review Gut flora Enteric Nervous System Epithelium 0302 clinical medicine Myenteric plexus Neurons 0303 health sciences Gastrointestinal tract MYENTERIC PLEXUS Microbiota GUINEA-PIG INTESTINE SMOOTH-MUSCLE Brain CHAIN FATTY-ACIDS Molecular Medicine Neuroglia Life Sciences & Biomedicine Signal Transduction GLIAL-CELLS Biochemistry & Molecular Biology Biology Neuroimmune 03 medical and health sciences Cellular and Molecular Neuroscience Immune system Glia Animals Humans NITRIC-OXIDE SYNTHASE Molecular Biology 030304 developmental biology Pharmacology Science & Technology PRIMARY AFFERENT NEURONS Enteric circuitry Cell Biology biology.organism_classification Gastrointestinal Microbiome Gastrointestinal Tract Intestinal homeostasis SUBMUCOUS NEURONS Immune System Enteric nervous system MIGRATING MOTOR COMPLEX Neuroscience 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Cellular and Molecular Life Sciences |
| Popis: | The enteric nervous system (ENS) is an extensive network comprising millions of neurons and glial cells contained within the wall of the gastrointestinal tract. The major functions of the ENS that have been most studied include the regulation of local gut motility, secretion, and blood flow. Other areas that have been gaining increased attention include its interaction with the immune system, with the gut microbiota and its involvement in the gut-brain axis, and neuro-epithelial interactions. Thus, the enteric circuitry plays a central role in intestinal homeostasis, and this becomes particularly evident when there are faults in its wiring such as in neurodevelopmental or neurodegenerative disorders. In this review, we first focus on the current knowledge on the cellular composition of enteric circuits. We then further discuss how enteric circuits detect and process external information, how these signals may be modulated by physiological and pathophysiological factors, and finally, how outputs are generated for integrated gut function. ispartof: CELLULAR AND MOLECULAR LIFE SCIENCES vol:77 issue:22 pages:4505-4522 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
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