Effectiveness of transdermal nicotine patch in premenopausal female smokers is moderated by within-subject severity of negative affect and physical symptoms
| Autor: | Andrea J. Rapkin, Raina D. Pang, Adam M. Leventhal, Tory A. Eisenlohr-Moul, Matthew G. Kirkpatrick, Lina M. D'Orazio, Stephanie H. Chai |
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| Rok vydání: | 2020 |
| Předmět: |
Transdermal patch
medicine.medical_treatment Medical and Health Sciences Nicotine 0302 clinical medicine Female smokers Follicular phase Transdermal nicotine patch Medicine media_common Psychiatry Smokers Smoking Pain Research Substance Abuse Tobacco Use Cessation Devices Transdermal nicotine Treatment Outcome Administration Female Chronic Pain medicine.drug Adult medicine.medical_specialty Drug Abuse (NIDA Only) media_common.quotation_subject Nicotine patch Clinical Trials and Supportive Activities Pain Placebo Administration Cutaneous Article Cigarette Smoking 03 medical and health sciences Clinical Research Internal medicine Sex differences Behavioral and Social Science Tobacco Humans Negative affect Menstrual cycle Pharmacology Tobacco Smoke and Health business.industry Contraception/Reproduction Prevention Psychology and Cognitive Sciences Neurosciences 030227 psychiatry Affect Cutaneous Premenopause Smoking cessation Smoking Cessation business 030217 neurology & neurosurgery |
| Zdroj: | Psychopharmacology, vol 237, iss 6 Psychopharmacology (Berl) |
| Popis: | RationaleNicotine patches may be less effective in female compared with male smokers. However, it is unknown if negative affect and physical symptoms influence transdermal nicotine patch-related effects on smoking behaviors.MethodsEighty-one acutely tobacco-abstinent premenopausal female smokers attended three counter-balanced experimental sessions across the menstrual cycle (early follicular, late follicular, and mid-luteal) and were randomized to patch condition (nicotine [21mg] vs. placebo [0mg] transdermal patch). Negative affect and physical symptoms were assessed prior to patch administration. The patch was removed 5h post-administration, and participants completed a smoking reinstatement task. Multilevel linear models tested associations of patch condition, negative affect and physical symptoms, and their interaction on smoking behavior.ResultsThere was a significant patch condition × Negative Affect and Pain symptoms interaction on the number of cigarettes smoked (p |
| Databáze: | OpenAIRE |
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