The opposite correlation between calcium ion and cyclic-AMP regarding the activation of microsomal triglyceride transfer protein in rat liver
| Autor: | Hyo-Chan Kang, Young-Bin Yu, Hyeong-Soo Kim, Hwa-Jin Park, Man Hee Rhee, Hyun-Jeong Cho, Dong-Ha Lee, Jae Youl Cho |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Thapsigargin chemistry.chemical_element Calcium Biochemistry Microsomal triglyceride transfer protein Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Cyclic AMP Animals Cyclic adenosine monophosphate Molecular Biology Triglycerides Calcium metabolism Triglyceride biology Hypertriglyceridemia General Medicine Feeding Behavior medicine.disease Rats Endocrinology Glucose chemistry Bucladesine Liver Microsome biology.protein Carrier Proteins |
| Zdroj: | BMB reports. 42(10) |
| ISSN: | 1976-6696 |
| Popis: | In this study, the effects of Ca(2+) and cyclic adenosine monophosphate (cAMP) on microsomal triglyceride (TG) transfer protein (MTP) activity were investigated in rat liver. MTP activity was high when liver contained low levels of cAMP, which was induced by administration of glucose, or high levels of total Ca(2+) and TG. However, MTP activity increased by high levels of Ca(2+) and TG was reduced in a dose-dependent manner by treatment with dibutyryl-cAMP (db-cAMP), a cAMP analogue. Conversely, when homogenates of liver from normal rats, with low levels of total Ca(2+) and high levels of cAMP, were incubated with thapsigargin, a Ca(2+)-inducer, MTP activity was increased in a dose-dependent manner compared to control. Therefore, our results suggest that high levels of Ca(2+) cause hypertriglyceridemia through the elevation of MTP activity, as opposed to high levels of cAMP, which suppress MTP activity and inhibit hypertriglyceridemia. |
| Databáze: | OpenAIRE |
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