| Autor: |
Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia |
| Rok vydání: |
2023 |
| Popis: |
This file shows the Supplementary figures. Figure S1 shows the chemical structure of EGF816 and its binding to EGFR T790M mutant. Figure S2 shows the tolerability of EGF816 in the in vivo xenograft models. Figure S3 shows the in vivo PK and PD after a single dose of EGF816. Figure S4 shows the selectivity profile of EGF816 in the kinome tree. Figure S5 shows the morphology of EGF816 resistance clones. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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