Association between Glycemic State and Lung Function
| Autor: | George T. O'Connor, Robert E. Walter, Rachel J. Givelber, Daniel J. Gottlieb, Alexa S. Beiser |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
Male Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Vital Capacity Critical Care and Intensive Care Medicine Pulmonary function testing Diabetes Complications Pulmonary Disease Chronic Obstructive Framingham Heart Study Predictive Value of Tests Risk Factors Forced Expiratory Volume Diabetes mellitus Internal medicine Diabetes Mellitus Humans Medicine Aged Glycemic Framingham Risk Score medicine.diagnostic_test business.industry Smoking Case-control study Fasting Middle Aged medicine.disease Respiratory Function Tests Cross-Sectional Studies Logistic Models Endocrinology Case-Control Studies Cohort Linear Models Regression Analysis Female business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 167:911-916 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.2203022 |
| Popis: | Diabetes mellitus has been inconsistently associated with a reduced level of pulmonary function. To elucidate this association further, we analyzed the relationship of diabetes and of fasting blood glucose to the level of pulmonary function assessed by spirometry in the 3,254 members of the Framingham Offspring Cohort. Diabetes was defined as a fasting blood glucose of 126 mg/dl or more or pharmacologic treatment. Subjects were classified as current, former, or never smokers based on questionnaire responses. Predicted pulmonary function was determined from the coefficients of a regression of pulmonary function on age, sex, and body habitus in the 1,110 never smokers. Both the diagnosis of diabetes and a higher level of fasting blood glucose were associated with lower than predicted levels of pulmonary function. The adverse effect of diabetes and glycemic level on pulmonary function was stronger among ever smokers than never smokers, suggesting an interaction between the level of fasting glycemia and tobacco smoking. |
| Databáze: | OpenAIRE |
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