Synthesis, in vitro and in vivo preliminary evaluation of anti-angiogenic properties of some pyrroloazaflavones
| Autor: | Barbara Oselladore, Pier Paolo Parnigotto, Diego Guidolin, Maria Grazia Ferlin, Luca Urbani, Rosa Di Liddo, Maria Teresa Conconi |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Magnetic Resonance Spectroscopy Angiogenesis Clinical Biochemistry Pharmaceutical Science Angiogenesis Inhibitors Apoptosis Biochemistry Umbilical vein Mice Cell Movement In vivo Drug Discovery medicine Animals Humans Pyrroles Fibroblast Molecular Biology Cells Cultured Phenyl-pyrroloquinolinones Aza Compounds Chemistry Anti-vascular agents Organic Chemistry Biological activity Flavones In vitro Cell biology Mice Inbred C57BL Endothelial stem cell medicine.anatomical_structure Pyrroloazaflavones Immunology Molecular Medicine Human umbilical vein endothelial cell Endothelium Vascular Pyrroloazaflavones Phenyl-pyrroloquinolinones Angiogenesis Anti-vascular agents |
| Popis: | This work investigated the in vitro and in vivo anti-angiogenic activity of some pyrroloazaflavones, exactly 2-phenyl-1H-pyrrolo[2,3-h]quinolin-4(7H)ones, with vinblastine as reference compound. Growth inhibitory activity, migration, and capillary-like structures formation were determined in human umbilical vein endothelial cell cultures, and Matrigel plug assay was carried out to evaluate in vivo effects on angiogenesis. Collectively, our results indicate that some pyrroloazaflavone derivatives, at non-cytotoxic concentrations and like vinblastine are able: (i) to exert in vitro anti-angiogenic activity and (ii) to counteract in vitro and in vivo the pro-angiogenic effects of fibroblast growth factor-2 (FGF-2). |
| Databáze: | OpenAIRE |
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